Metoprolol and amiodarone are not suitable for simultaneous administration. Metoprolol is a beta-blocker and amiodarone is a class III antiarrhythmic drug, which belongs to the broader-spectrum antiarrhythmic drugs, both of which have the effect of slowing down the heart rate, and taking them at the same time may result in a serious slowing down of the heart rate, so it is not suitable for simultaneous administration. Metoprolol is a beta-blocker, clinically used in the treatment of tachycardia, hypertension and other diseases, can slow down the heart rate, inhibit myocardial contractility, oral need to monitor the heart rate, when the heart rate is slow is not suitable for application. Amiodarone is the third class of antiarrhythmic drugs, atrial arrhythmia, ventricular arrhythmia have a clear therapeutic effect, thyroid function abnormalities, interstitial fibrosis, liver function abnormalities should not be used, but also slows the heart rate, so when the heart rate is too slow is contraindicated. Metoprolol and amiodarone, if taken at the same time, may cause excessive slowing of the heart rate, which may be dangerous, and it is not recommended to take them at the same time. The use of antiarrhythmic drugs requires a cardiology consultation under the guidance of a specialized physician.