Tubal patency and non-pregnancy may be related to ovulatory disorders, cervical and uterine lesions, but also need to consider the male reproductive system lesions, congenital anomalies and other causes. 1. Ovulation disorders: common in ovarian pathology, such as polycystic ovary syndrome, early onset ovarian insufficiency, functional ovarian tumors, chromosomal abnormalities and so on. Next is hyperprolactinemia, pituitary tumor and other hypothalamic and pituitary lesions. It also includes amenorrhea caused by excessive obesity and excessive exercise. 2. Uterine lesions: clinically, it is mostly seen in endometrial lesions, uterine fibroids, uterine adhesions and so on. 3. Reproductive system lesions: mostly considered to be the presence of retrograde ejaculation, erectile dysfunction, varicocele, epididymitis, seminal vesiculitis, prostatitis and other diseases in men. 4. Congenital anomalies: if men have congenital absence of vas deferens and seminal vesicles, congenital testicular dysplasia, incomplete testicular descent, Y chromosome microdeletion and so on, then it may also affect women’s pregnancy. To summarize, if the fallopian tube is clear but not pregnant, it is recommended that both husband and wife go to the hospital for relevant examinations to clarify the specific causes.