Itchy skin all over the body after thyroid surgery may be related to hypothyroidism, pruritus, drug dermatitis, etc. It can be relieved by general treatment, medication and surgery. 1. Hypothyroidism: Post-operative hypothyroidism may cause itchy skin, patients should pay attention to keep warm, avoid infection and other stressful conditions, and can take levothyroxine, iodoselenin, dry thyroid tablets and other medications under the guidance of the doctor to relieve itchy skin. 2. Pruritus: Patients should avoid contact with triggering factors and avoid scratching, rubbing and scalding the skin. It can also be treated with topical medications under the guidance of a doctor, such as glycerite lotion, doxepin ointment, pimecrolimus and other medications, as well as isoprinosine, nicotinamide, procaine hydrochloride and other systemic treatments. 3. Drug dermatitis: when patients with postoperative drug dermatitis, can cause generalized itching of the skin, the patient can take antihistamines under the guidance of the doctor, such as cetirizine, loratadine, etc.; topical drugs, such as glycerine lotion, eschazepam, etc., for wet compresses, but also can be coated with dexamethasone ointment, ice floridone easy cream, etc., to carry on the treatment. It is recommended that patients strictly follow the doctor’s instructions, do not change the dose of drugs or private abuse of drugs, so as not to affect the therapeutic effect, etc., should also pay attention to the monitoring of the condition in life, once the condition worsens or other uncomfortable symptoms need to seek medical treatment in a timely manner.