Sweat herpes belongs to a special type of hand eczema. It occurs on the palmoplantar and lateral margins of the fingers (toes). It can be treated by general therapy, topical medications, oral medications, and physical therapy. Topical glucocorticoid is the first-line treatment drug for herpes sweat. 1. General treatment: pay attention to the protection of skin lesions in daily life, avoid friction and scratching. Pay attention to clean and moisturize the hands. 2. Topical medication: topical glucocorticosteroids such as mometasone furoate can be used, in addition, calcium-modulated neural phosphatase inhibitors (such as tacrolimus ointment, pimecrolimus cream) also has a better efficacy. The use of specific drugs should be under the guidance of a doctor. 3. Oral medication: When itching is severe and affects sleep, antihistamines such as loratadine can be considered, and antibiotics such as cefprozil can be added for those with secondary bacterial infections. 4. Physical therapy: Narrow-spectrum medium-wave ultraviolet light (NB-UVB) and UVA1 can be used to treat herpes sweat. Sweat herpes patients are recommended to seek medical advice in a timely manner, under the guidance of a doctor to standardize the treatment, the medication should be used in accordance with the doctor’s instructions, do not self-medication.