It is not normal to feel tingling for a few days after applying imiquimod several times and stopping the medication. After topical application, imiquimod can induce a variety of cytokines and related products, thus producing immunomodulation and indirect antiviral effects. It is mainly used for the treatment of adult external genital and perianal condyloma acuminatum. Usually, when the drug is used locally, it may cause itching, burning sensation, pain and other discomforts at the wart site or at the distant site of the wart. However, these symptoms usually disappear after stopping the medication. If you still feel tingling after a few days of stopping the medication, this is not normal and may be due to the patient’s allergy to the components of the medication. Allergy to the drug, may be in the process of using the drug, or even after stopping the drug for a period of time, the local skin serious adverse reactions, such as erythema, vesicles, tingling, etc., at this time, the drug should be immediately stopped, the local application of mild soapy water or water to wash, and immediately consult a doctor. If you still feel tingling when applying imiquimod several times and stopping for a few days, it is recommended that the patient seek immediate medical attention and treatment under the guidance of a doctor.