Desensitizing toothpaste can be used for a long time. Chronic wear of teeth occurs, jaw enamel disappears, dentin is exposed in the mouth, and sensitivity symptoms can occur when cold, hot, sour, sweet and other stimuli are encountered. Patients can apply desensitizing toothpaste, which contains drugs such as strontium chloride, which can be coated on the tooth surface under the repeated action of bristles to seal the ends of dentin tubules, block the transmission of stimuli and improve the symptoms of sensitivity. During daily chewing and eating, the teeth are constantly rubbed, causing the ends of the dentin tubules to reopen, requiring long-term application of desensitizing toothpaste. In addition to the anti-allergic effect of the drug, desensitizing toothpaste can also clean the tooth surface by friction agent, reduce the retention of food residue and soft scale, and prevent the occurrence of caries damage, which will not have adverse effects on human body and can be used safely for a long time.