Soreness on both sides of the spine may be caused by physiological factors or pathologic factors, such as ankylosing spondylitis, lumbar muscle strain, lumbar intervertebral disc herniation and so on. 1. Physiological factors: muscle fatigue caused by sitting for a long time or in one position for too long, and soreness on both sides of the spine caused by cold stimulation of the back may also occur, and the symptoms can be alleviated with appropriate activities. 2. Ankylosing spondylitis: Soreness on both sides of the spine can also occur, with obvious pain at night, morning stiffness, and limited spinal activity. 3. Lumbar muscle strain: prolonged exertion caused by chronic strain on the muscles of the lumbar back, muscle spasm, soreness on both sides of the spine, bending activities are limited. If the spinal pain on both sides of the back does not improve with rest, it is recommended to go to the hospital in time for examination and treatment.