The drug omeprazole can be taken as prescribed by your doctor about one to two hours after drinking alcohol. Omeprazole is a proton pump inhibitor that works primarily by inhibiting the secretion of stomach acid and pepsin. Omeprazole is usually taken about half an hour before a meal. After drinking alcohol, ethanol will have a strong stimulating effect on the mucous membrane of the gastrointestinal tract, resulting in the occurrence of nausea and vomiting and other symptoms, and then take omeprazole one to two hours after drinking alcohol, omeprazole can be very good inhibition of gastric acid secretion so as to alleviate the symptoms, but also to prevent the ingestion of ethanol to reduce the efficacy of omeprazole and the two produced by the interactions of the adverse reactions. If you usually have peptic ulcer, stomach bleeding and other patients who need to use Omeprazole, it is best to quit drinking to reduce the damage of ethanol on the digestive tract.