Hair follicle shrinkage and closure, whether it can be recovered or not, is related to the triggering cause. Physiological follicle shrinkage, generally can be natural recovery. Disease causes hair follicle atrophy, it is recommended to treat as early as possible, can be gradually recovered. If the hair follicle destruction is serious, usually can not be restored. 1. Physiological factors: Hair follicles are in the cycle of anagen, regression and resting phase. After a period of growth, hair follicles may shrink physiologically and enter the resting phase, and then enter the anagen phase with the passage of time to form a new follicular structure, and follicular atrophy may gradually recover. 2. Pathological factors: bacterial and fungal infections lead to the destruction of hair follicles, early in the disease, hair follicles are not seriously damaged, anti-fungal, anti-inflammatory treatment, can be regenerated and repaired at a later stage. If the damage is serious, usually can not be repaired. If seborrheic alopecia can be intervened early, follicular atrophy can be delayed. If it is already in the later stages of the disease and the follicles shrink, it is very difficult to restore them. To summarize, there are more reasons for follicle shrinkage and closure, and it is suspected to be caused by pathological factors, so it is recommended to treat it as early as possible to avoid the formation of permanent hair loss.