There are always accidents that happen in normal life and some people suffer from cranial defects due to various accidents. The role of the skull is irreplaceable, and cranial defects must be cranial repair surgery to better restore health. Cranial defects are not a problem to be taken lightly. If left untreated, they can lead to a series of neurological dysfunctions, and can also lead to a number of syndromes, such as dizziness, nausea and chills, and loss of muscle strength in the limbs, among others. There are also cranial defects can lead to severe cerebral edema, resulting in localized ischemic necrosis of the brain, causing a variety of neurological localization symptoms. Therefore, once the cranial bone defect, timely examination and treatment in regular hospitals is the key. In the process of cranial repair surgery, there are many factors affecting the postoperative results, such as the time of surgery, the hospital chosen, experts and materials, etc.. Generally speaking, most of the cranial injuries caused by trauma or surgery, etc., should be carried out after three months before cranial bone repair surgery. As for the materials for skull repair surgery, there are a lot of materials in medicine, such as plexiglass in the early stage, bone cement, titanium alloy and so on in the later stage. However, after a series of clinical verification shows that these ordinary materials have certain defects, and patients will have various physical rejection reactions after surgery, so in order to better achieve good results after surgery, it is very necessary to choose a safer material. In the choice of cranial bone repair materials, the new PEEK material, more secure and advanced, hard and flexible, not easy to deform. This PEEK material can be very good heat insulation, strong stability, three-dimensional molding, anastomosis is extremely high, is currently the best choice of material for skull repair surgery.