Leukoarai syndrome is a systemic immune system disorder with clinical symptoms similar to those of leukoaraiosis. It is different from leukoaraiosis because of the presence of other diagnosed but diseases of the whole body. It has clinical symptoms: in addition to the symptoms of the primary disease, it can be accompanied by recurrent oral and perineal ulcers, rash, and ocular symptoms. In terms of symptoms, it is difficult to distinguish from the symptom items of leukoaraiosis, such as typical symptoms oral ulcers, genital ulcers, ocular lesions, clinical manifestations such as eye redness, pain, photophobia, or vision loss. Skin manifestations are facial, chest and back, and other parts of the pimple-like rash, etc., joint pain or swelling, difficulty swallowing, or swallowing chest pain, acid reflux, heartburn and other gastrointestinal symptoms, vascular lesions, inflexibility of the hands and feet, headache, dizziness and other neurological disorders, and may be accompanied by other symptoms such as weakness, poor nausea, low fever, wasting and other systemic symptoms.