Children with precocious puberty are likely to have premature development of bone age and premature epiphyseal closure before they reach the developmental age, resulting in their generally shorter size in adulthood. The epiphysis is the center of secondary ossification that occurs at different times after the birth of a child, and the epiphysis and epiphyseal plate are the growth areas of immature limb bones, and the weakest and most prone to fracture of the bones of a child. So, how to check for premature epiphyseal closure? The following examination introduces the examination items of premature epiphyseal closure: General X-ray fluoroscopy can confirm whether the epiphysis is prematurely closed. The diagnostic examination of precocious puberty: a detailed and complete medical history, including the development of sexual characteristics, vaginal bleeding, whether to take endocrine drugs. Radioimmunoassay to measure follicle stimulating hormone FSH and LH can help to differentiate between true and pseudo precocious puberty. In somatic precocious puberty, there may be enlarged ovaries and cystic changes. Retroperitoneal insufflation angiography may be performed when adrenocortical disorders are suspected. Frontal and lateral images of the skull, observe the size of the pterian saddle in order to exclude tumors. 1, plasma FSH, LH measurement; 2, bone age determination; 3, ultrasound examination; 4, CT or MRI examination; 5, other tests: according to the clinical manifestations of the child can be further selected.