Creatinine 104.8μmol/L, urine with foam, may be impaired renal function, there may be glomerular or tubular disease, it is recommended to consult a doctor in time, after clarifying the cause of the disease for the treatment of the primary pathology, as well as for the protection of renal function treatment. Blood creatinine is one of the renal function tests, which can reflect the glomerular filtration rate to a certain extent. When creatinine is elevated, it indicates that the renal function is impaired, the glomerular filtration rate decreases, and the proteins in the original urine leak out into the final urine, forming foamy urine. Common kidney diseases such as nephrotic syndrome and nephritic syndrome. Nephrotic syndrome is categorized into primary glomerular disease and secondary glomerular disease according to the cause. Nephritic syndrome includes acute nephritic syndrome, acute progressive nephritic syndrome, and chronic nephritic syndrome, all of which can lead to elevated creatinine with proteinuria. The key to treatment is to treat the cause of the disease, such as acute nephritis requires anti-infective symptomatic treatment; such as chronic nephritis requires clear disease typing, and then relevant immunotherapy. Symptomatic supportive treatment includes kidney protection, lowering urinary protein, etc. Meanwhile, limiting the excessive intake of vegetable protein and recommending a high-quality animal protein diet. The diagnosis of the disease is the key to the treatment, therefore, if you have high creatinine with foamy urine, it is recommended to consult a doctor in time, under the guidance of a professional doctor, to make a clear diagnosis and standardize the treatment.