High peroxidase antibodies can be triggered by a variety of conditions, but they need to be evaluated in conjunction with specific clinical symptoms and other physical examination indicators. First of all, the most common organ with elevated peroxidase antibodies is the thyroid gland, but thyroid peroxidase antibodies are not a clear indicator of the condition. Peroxidase antibodies are usually found in thyroiditis and hyperthyroidism, but they can also be affected by normal physiological functions such as mood swings or fever. Therefore, when peroxidase antibodies are elevated on physical examination, the cause of the elevation should be investigated promptly. If the elevation is due to normal fluctuation of physiological functions, then it is only necessary to adjust the work routine and wait for the elevation to recover. If the elevation is due to thyroid dysfunction or autoimmune disease, then symptomatic treatment is needed to address the root cause of the elevated peroxidase antibodies. In the process of clinical examination, we can not easily judge the condition just because of the fluctuation of a certain index, we need to analyze from multiple angles to give the most scientific judgment.