Pulmonary blisters are caused by elevated pressure in the alveoli, and the walls of the alveoli rupture and fuse with each other to form a huge vesicle-like change, which is called pulmonary blister. The clinical manifestations of pulmonary blisters are closely related to the number and size of the blisters and the presence of chronic diffuse obstructive pulmonary disease. Smaller simple pulmonary blisters with low numbers may have no clinical symptoms. They are sometimes detected occasionally on X-ray or during dissection for other lung diseases. The main risk of pulmonary blisters is that they may rupture and produce spontaneous pneumothorax. The main treatment is to perform occlusion and drainage or to perform surgery to remove the pulmonary blister. If there is a combined lung infection, oral anti-inflammatory drugs can be considered.