Odontogenic clear cell carcinoma belongs to malignant tumor, and local metastasis may occur after recurrence, which can be life-threatening in advanced stage, so it is recommended not to panic and treat it actively. Odontogenic clear cell carcinoma is a malignant tumor with infiltrative and rapid growth, which can be metastasized to distant places along lymphatic blood. After recurrence, surgical resection of tumor and adjacent tissues is needed, along with lymphatic dissection. At the same time of surgical treatment, combined with radiotherapy and chemotherapy, comprehensive sequence treatment is adopted, and reasonable and effective treatment means are designed according to the situation of recurrence and individual’s general physical condition. It is suggested that after checking the specific situation of odontogenic clear cell carcinoma, relaxing the mentality and actively cooperating with doctor’s treatment is conducive to recovery.