Tetanus Immunoglobulin is a biological agent used to prevent tetanus that is produced through a complex process. Tetanus immunoglobulin injection is a kind of passive immunity, which means that the immune effect can be produced quickly after the injection, but the duration is short, with a maintenance time of 2 weeks. If the human body is injured, in addition to timely cleaning and treatment of the wound, it should also be promptly injected tetanus antitoxin. However, it should be noted that the injection of tetanus antitoxin may produce allergic reactions, so before the injection of tetanus antitoxin need to do a skin test, if the skin test is negative, you can directly inject tetanus antitoxin, if allergic to tetanus antitoxin, you can complete the injection through desensitization therapy or switch to tetanus immunoglobulin, so as to effectively stop the onset of tetanus. In general, there are no obvious adverse reactions to tetanus immunoglobulin injections. Very few people will have redness, swelling and pain at the injection site, but no special treatment is needed and they can recover slowly. There are no special contraindications to the use of tetanus immunoglobulin. However, tetanus immunoglobulin is after all a protein preparation and should be prohibited for people who have allergies to protein-based products. In conclusion, tetanus immunoglobulin is used to prevent and treat tetanus, and there are no special contraindications in its use.