Neonatal tetanus is the main disease that threatens the life and health of newborns, once the infection triggers masticatory muscle spasm, treatment is more difficult, but neonatal tetanus can be completely effective prevention. Newborns are generally susceptible to tetanus bacilli, so they should: 1. New method of delivery Vigorously promote the new method of delivery. Scissors should be red with fire, cooled or scissors coated with 2% iodine to dry after breaking the umbilical cord, the cord should also be disinfected with 2% iodine and ligated umbilical cord, and leave more umbilical cord stump for a few centimeters, and strive to re-treat the umbilical cord within 24h according to the strict disinfection method. Cut off the distal end of the residual umbilical cord and retie it again. 2.Emergency In case of emergency, in addition to cord treatment by strict disinfection, at the same time: (1) Penicillin: intramuscular injection of penicillin for 3 to 4 days. (2) Tetanus antitoxin: intramuscular injection of tetanus antitoxin 1500 ~ 3000 U. (3) Tetanus immunoglobulin: intramuscular injection of body tetanus immunoglobulin 75 ~ 250 U. 3, pregnant women intramuscular injection of tetanus toxoid Because maternal antibodies and neonatal antibodies are positively correlated. The level of tetanus antitoxin in antibody serum at 0.01U/ml can effectively protect the body from tetanus infection. For pregnant women who cannot ensure aseptic delivery, two injections of tetanus toxoid 0.5ml can be given in late pregnancy, 1 month apart, and the second one is given intramuscularly at least 2 weeks before delivery (preferably at 1 month). Domestic reports on China’s women of childbearing age with protection level is only 38.22%, the mainland is higher than remote areas. Since there is a potential risk of neonatal tetanus in remote areas, immunization against tetanus toxoid in women of childbearing age or pregnant women should be carried out as soon as possible. The infant should be protected from infection by increasing the immunity level of the mother.