Intracranial infections after craniotomy are usually treated with antibiotics combined with lumbar large pool drainage, and can usually be cured in about two weeks, with some patients with more severe infections taking longer. Intracranial infection caused by craniotomy is generally feasible lumbar puncture for cerebrospinal fluid laboratory tests and culture, plus drug sensitivity test, according to the results of the doctor’s orders to choose the appropriate antibiotic (such as ceftazidime, etc.) treatment, usually about two weeks intracranial infection can be cured. For some patients with more serious infection, antibiotic treatment can be accompanied by lumbar pool drainage to achieve the purpose of cerebrospinal fluid replacement, generally lumbar pool drainage can usually be effective in about a week, the longest use of time does not exceed two weeks. In addition, for some prolonged intracranial infections, there is also the option of craniotomy abscess aspiration, incision and drainage and other surgery, which may take longer. It is recommended that patients who develop intracranial infections after craniotomy should seek timely medical attention and be treated actively under the guidance of their doctors to avoid delays.