Swollen and painful submandibular lymph nodes are usually due to oropharyngeal infections. The pathogens that cause the infection include bacteria, virus, tuberculosis and so on, and it is necessary to choose the appropriate medication according to different pathogens. 1. Bacterial infection: mostly caused by pharyngitis, gingivitis, pulpitis, tonsillitis, etc., can take amoxicillin, azithromycin, cefaclor and other antibiotics; accompanied by obvious pain, fever and other symptoms, can take ibuprofen, acetaminophen and other drugs. 2. Viral infection: Acyclovir, ribavirin and other antiviral drugs can be taken for treatment; when accompanied by obvious pain, fever and other symptoms, ibuprofen, acetaminophen and other drugs can be taken for treatment. 3. Lymphatic tuberculosis: often accompanied by low fever, night sweats, emaciation and other symptoms of tuberculosis poisoning, can follow the doctor’s instructions to take isoniazid, rifampicin, ethambutol and other drugs treatment. The lymph nodes under the jaw are swollen and painful, so we suggest that you consult a doctor in time to determine the cause of the problem and then choose a targeted drug treatment.