It is possible to get the new crown vaccine during the stabilized stage of ankylosing spondylitis. Ankylosing spondylitis, also known as AS, is a rheumatologic immune disease, mainly characterized by inflammation of the spinal attachment points and sacroiliac joints as the typical clinical symptoms. It is often combined with different degrees of cardiovascular lesions, intestinal tract, lungs and other extra-articular manifestations, and spinal deformity and spinal ankylosis can occur with prolonged and continuous development. In the stabilized stage of ankylosing spondylitis, there is no pain in the spine and peripheral joints, and there is no chest pain or stiffness in the neck during activities, and there is no double hip pain at night. What’s more crucial is that laboratory indicators such as blood sedimentation, C-reactive protein and serum are in the normal range. Therefore, ankylosing spondylitis lives like a normal person when it is stable and there are no contraindications for the new crown vaccine. However, the vaccine should be administered under the guidance of a doctor and the condition should be properly monitored. If the ankylosing spondylitis is in the active stage, it is recommended that the patient be treated actively to control the symptoms and wait until the disease has stabilized before receiving the vaccine in order to prevent any adverse reactions. The vaccine can be given during the stabilized stage of ankylosing spondylitis, but it should be given under the supervision of a doctor and the condition should be monitored properly. If the ankylosing spondylitis is still in the acute stage, it needs to be treated and controlled to the stabilized stage before vaccination in order to avoid causing adverse reactions.