Fibrates are generally less commonly taken together with anti-inflammatory painkillers in clinical practice, but they can be taken together with anti-inflammatory painkillers for certain patients who are in a special period of illness. Febuxostat is a commonly used uric acid-lowering drug that can lower blood uric acid levels and reduce the frequency of gout attacks. In the current treatment of gout, anti-inflammatory painkillers should be taken as early as possible during the acute attack to control joint symptoms. At this time, it is not recommended to advocate taking uric acid-lowering drugs such as febuxostat, and uric acid-lowering drugs such as febuxostat should be taken after the swelling and pain in the joints have disappeared and according to the blood uric acid level. However, for some patients, if they have already started to take febuxostat and other uric acid-lowering drugs and have a sudden acute attack of gout on the way, they can temporarily take anti-inflammatory painkillers to control joint symptoms without suspending oral febuxostat, and then suspend oral anti-inflammatory painkillers and continue to take febuxostat and other uric acid-lowering drugs after the joint swelling and pain disappears.