There is no cure for chronic lymphocytic leukemia. Chronic lymphocytic leukemia is a clonal proliferative tumor of mature B lymphocytes. Early stage chronic lymphocytic leukemia does not require treatment and regular follow-up is sufficient. Hemoglobin below 100 g/L, giant spleen, giant lymph node enlargement, and no infection but night sweats are indications for treatment. Slow gonorrhea is still an incurable disease and is recommended to enter clinical trials, in which ibrutinib is recommended for those without 17p and <65 years old with no serious disease, and zebrutinib and obrutinib can be considered. Greater than or equal to 65 years of age or with serious disease recommend ibrutinib, vinaclat + otuzumab and other treatments, debilitated patients consider phenylbutyrate nitrogen mustard + rituximab and other treatments for relief. Although slow gonorrhea can not be cured, but active treatment can relieve the symptoms of slow gonorrhea, the quality of life will also have a great improvement, it is recommended to cooperate with the doctor for active treatment.