Generalized itching after cholecystectomy can be considered as allergy, obstructive jaundice and other conditions, which need to be followed up as soon as possible for appropriate examination before symptomatic treatment. 1. Allergic or inflammatory reaction: If itching is accompanied by pimples and erythema after cholecystectomy, it should be considered as allergy or skin inflammation. It may be caused by the patient eating or contacting allergic substances, food, or allergic to the drugs used after the operation, and it is necessary to clarify the allergic substances as soon as possible, avoid re-exposure, and at the same time, take anti-allergic drugs such as loratadine tablets for relief. 2. Obstructive jaundice: after cholecystectomy, obstructive jaundice may be caused, in addition to generalized itching, there will be light stool color, yellow urine, yellow skin sclera and other symptoms. It is necessary to improve the liver function, upper abdominal ultrasound and other tests as soon as possible, avoid eating spicy and stimulating food, eat a light diet, if necessary, can be carried out biliary tract intervention (endoscopic retrograde cholangiopancreatography). If generalized itching occurs after cholecystectomy, it is necessary to diagnose the disease as soon as possible according to other symptoms, and at the same time carry out medication and surgical treatment to control the development of the disease. It is recommended that the patient should contact the responsible doctor in time if there are uncomfortable symptoms after cholecystectomy, and review the ultrasound and liver function regularly to avoid delaying the condition.