Hypoechoic thyroid nodule with calcification may be benign thyroid nodule or thyroid cancer; benign thyroid nodule with small size can be examined regularly, while thyroid cancer needs to consider surgery. Hypoechoic thyroid nodule with calcification is a kind of description under thyroid ultrasound. Hypoechoic nodule indicates that the echogenicity of the thyroid nodule is lower than that of the surrounding thyroid parenchyma, whereas calcification, if manifested as coarse calcification, usually suggests that the likelihood of the benignity of the thyroid nodule is high, and at this time, if the patient’s thyroid nodule is not too small in size, regular checkups are sufficient, and there is no need to have any special treatment. If the calcification is sandy, the possibility of malignancy is high, and puncture biopsy is necessary. Once thyroid cancer is diagnosed, surgical resection is needed, and levothyroxine replacement therapy may be needed after surgery. If hyperechoic thyroid nodules with calcification appear, it is recommended to go to the hospital and ask the doctor to make a judgment.