The targets of hepatitis B vaccination are mainly newborns, followed by infants and children, unimmunized people under 15 years of age and high-risk groups (such as medical personnel, people who are frequently exposed to blood, workers in childcare institutions, organ transplant patients, people who frequently receive blood transfusions or blood products, people with low immune function, people prone to trauma, family members of HBsAg-positive people, men who have sex with men or multiple sexual partners and people who inject drugs intravenously). The hepatitis B vaccine is required to be administered for 3 weeks.) Three doses of hepatitis B vaccine are required for the entire course, according to the 0, 1 and 6 months procedure, i.e., after the first vaccination, the second and third doses are given at intervals of 1 month and 6 months. Hepatitis B vaccination for newborns should be given within 24 hours of birth, the earlier the better. The vaccination site is intramuscular in the lateral anterior gluteal muscle for newborns, and intramuscular in the middle deltoid muscle of the upper arm for children and adults. Du Lei, Ai Research Center, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine