One depressive episode in a lifetime is painful enough, but for some people with depression, depression is like a spell that is hard to shake off and can recur frequently. Usually, ≥3 episodes indicate the need for long-term antidepressant treatment, so it is important not to take depression lightly even after it is cured, and to seek medical attention as soon as you catch the danger signs of relapse. So what are the signs of depression relapse? NO.1 Sadness, despair, depression or “empty, meaningless” feeling reappears. NO.2 Loss of enthusiasm for work, absent-mindedness, avoidance of social situations. NO.3 Poor sleep, difficulty sleeping through the night or prolonged sleep. NO.4 Irritability and frequent outbursts of anger. Men are more likely than women to experience this condition. NO.5 Loss of sexual interest, interest, and indifference to family members. NO.6 Decreased self-esteem, gradual return of self-loathing and guilt, preoccupation with obsessing over failure. NO.7 Chronic pain with unknown causes and various locations. NO.8 Weight change, loss of interest in food or overeating. NO.9 Fatigue, some daily activities such as dressing, washing dishes, etc. can overwhelm you and exhaustion. NO.10 Slow thinking, easily distracted, unable to concentrate, memory loss. NO.11 Suicidal ideation is a very serious warning sign! If one or more of the above red flags appear and persist for more than 2 weeks, the possibility of a relapse of depression is high, so please consult with a professional as soon as possible.