Quadrivalent vaccine generally refers to quadrivalent human papillomavirus vaccine. The price of domestic vaccine will be affected by manufacturers and other factors, usually about 800 yuan for one vaccine, and a total of about 2,400 yuan. The price of domestic quadrivalent HPV vaccine will fluctuate due to different manufacturers, different distributors, different packaging, different regions, different hospitals, etc. There is no exact pricing, usually the price of one unit is around 800 RMB, and a total of three injections are needed, so a total of about 2400 RMB is needed. Specific pricing needs to be consulted with local hospitals, and it is recommended that patients go to regular hospitals and ask about the relevant contraindications before choosing whether or not to receive the vaccination at their own discretion. The quadrivalent HPV vaccine can mainly prevent cervical cancer and other diseases caused by high-risk HPV types 16/18. After vaccination, patients may experience adverse reactions such as headache, fever, diarrhea, nausea and vomiting, myalgia, erythema, swelling, pain and itching. It is contraindicated for patients who are allergic to the vaccine and its excipients and other ingredients, and allergic reactions after injection should be treated immediately by a doctor.