First of all, we need to clarify the meaning of “good health”, is “good health” truly free of abnormalities? Does “good health” mean normal immune function? “Good health” is a relatively common expression, probably refers to: can eat, can sleep, muscle strength, look spiritual, usually less sick or not sick, etc.. The first few items can be achieved with good gastrointestinal function, good mood, no anemia, no disease in the motor system and active or passive exercise, and do not require much immune function involvement (as long as it is not too bad), so these good does not mean that the immune function is necessarily good. There are two types of illnesses: one is the subjective lack of attention and contempt for small problems, not treated as “illnesses”; the other is the lack of problems that do objectively manifest in the form of “illnesses”, which appear to be the absence of illnesses and may be It may be that the “disease” is relatively insidious, often found in organs with hidden locations, powerful compensations and poor “symptom” specificity, or it may be that the “cancer” itself does not manifest itself as a “disease”. It is also possible that the cancer itself does not appear in the way of “manifesting as disease first, then as cancer”. 1. Not all cancers have pre-cancerous diseases; 2. The pre-cancerous abnormalities are relatively insidious and appear as “no disease”, for example, cervical cancer occurs after more than ten years in a person with persistent HPV infection, during which there can be no symptoms (perceivable and detectable abnormalities), and until diagnosed, it has been regarded as A “healthy person in good health”. On the other hand, the seemingly “good health” does not mean that the local immune function is normal, and there are local abnormalities such as chronic inflammation, obstruction, poor defense function, etc. Many chronic inflammatory diseases do not show symptoms and are not considered to be “sick”, but they may be However, they may be on the way to become “cancer”. After talking about “good health”, let’s go back to the immune function. The occurrence of tumor is the result of multiple factors and links, which are at least two major factors: cancer-causing factor (enemy) and cancer-inhibiting factor (me). Therefore, immune function as part of “I” (other than genetic abnormalities, anatomical abnormalities, etc.) is certainly not the sole cause of cancer, but its partners and opponents are also worthy of attention. Among these two contradictions, the power of the “enemy” may take up a greater part in the occurrence of cancer, which is expressed in terms of phenomenon: most people have one kind of cancer in a specific area, and rarely see multiple primary cancers (there are also some), or even cancer all over the body, which means that it is not a problem with the “I Mechanically speaking, cancer cells will carry out a series of “bullying” measures on the immune system, such as “building up”, evading, pulling in and fighting, until the immune system is “pulled down”. “After all, even a good immune system has “blood” and “flesh”, it is not a piece of iron. In addition, there are also hereditary tumors. Many people in a family have gotten cancer one after another, because of the existence of powerful cancer-causing genes, even if the family is a sportsman, it is still difficult to escape the clutches of cancer (very often, it is just wishful thinking that man will win); there is another sportsman (no genetic background), who eats spicy food, hot pot and pickled food every day, but his body is still great, he can fight and dance, his body is good and his immunity is strong. But one day, he was found to have esophageal cancer, stomach cancer, you will certainly not be surprised, you will also say: he shall not, who has ah? Not to mention, those so-called good health and normal immunity, such as: can eat, can drink (big wine and meat), love sports (may be long-term bone and joint wear), etc., itself implies disease-causing and cancer-causing factors. These times, the immune system can only “shrug, show their hands”. In fact, the immune function is more of a surveillance and maintenance, an insurance rather than a safe. It is similar to the police in a society, which cannot act when there are criminals (immune deficiency) nor arrest when there are no criminals (autoimmunity), but must maintain a certain level of homeostasis. To some extent, a good social security can be partly considered as a better defense of the police (and possibly a higher quality of people); but a good defense of the police does not necessarily mean a peaceful society, because there are always various “natural” (genetic) “man-made” (man-made damage ) and “defenceless” (immune vulnerability, exemption area, weak area). Therefore, for individuals, those who have tumors are not necessarily immune weak; on the whole, the ratio of immune strong and immune weak in the conventional sense among people who have tumors may not be statistically different from normal people, at least when tumors have just occurred or not yet occurred (after tumors, especially in the advanced stage, immune function does decline significantly, which should be excluded). From another point of view, there are two major types of tumor immunotherapy: immune checkpoint inhibitors (including PD-1/PD-L1 antibodies and CTLA4 antibodies) and CAR-T, the former is to block the “brakes” in the immune response to revive the immune function of T cells, and the latter is to embed tumor-specific antigens into T cells. The former blocks the “brakes” in the immune response and revives the immune function of T cells, while the latter embeds tumor-specific antigens into T cells, giving them a pair of “eyes of gold” and making their immune capacity useful. Both of them have brought extraordinary efficacy, far surpassing previous non-specific immunotherapies, such as DC-CIK and LAK. Such results also confirm that the immune function of most tumor patients is not a problem in itself, but is more corrupted and blinded by the cunning tumor cells, and the enemy is indistinguishable from me. What needs to be done at this time is just to let the ability he has always had come into play, not to supplement the immune ability (because, there is no shortage of this). That said, it is also true that people with really poor immune function, such as AIDS patients or patients with long-term immunosuppressive applications (after organ transplants), are more likely to get cancer, and often multiple cancers, and more likely to have various infections in addition to cancer. That’s something that happens only when it gets quite bad, and has nothing to do with normal people and is not part of the discussion. So, to paraphrase a common saying: normal immune function is not everything, but no immunity is everything (still, you have to love your body).