According to the current diagnostic and therapeutic norms, the first infection with Mycoplasma urogenitalis generally requires the application of sensitive antibiotics for two weeks in accordance with the drug sensitivity results of the mycoplasma culture, followed by a two-week suspension of the drug and then a relevant retest. If the review result is negative, it is necessary to test for mycoplasma again after four weeks. If the review result is positive, then consider changing to other kinds of sensitive drugs, and then two weeks of treatment. During this time, the patient should suspend conjugal life and consider resuming only after the infection is completely controlled and clinically resolved. In addition, patients with relapses and those who have not been cured for a long time need to be treated differently according to the specific situation.