High glutamate is associated with factors such as alcohol consumption, liver and gallbladder disease, and medications. The main glutamate is glutamate dehydrogenase, a zinc-containing mitochondrial enzyme. The test result found high glutamate indicates that there is a problem in the liver, mainly considered to be directly related to the usual fondness for alcohol. The human body will go through the metabolism of the liver after drinking alcohol, and long-term heavy drinking will lead to liver damage, which will also cause high glutamate. By abstaining from alcohol, eating a light diet, and going to the hospital again at intervals for a liver function review. Some patients have liver dysfunction, hepatitis, and other liver diseases that can cause varying degrees of liver damage, which can also lead to high glutamate when examined in the hospital. Due to physical reasons some people will take drugs for a long time, such as cephalosporin, amoxicillin, erythromycin, hesperidin, rhubarb, etc., which are hepatotoxic and can cause damage to the liver when taken for a long time, so it can also cause high glutamate.