Morphine can become resistant after 3-5 days of continuous use and can become addictive after a week or more, so it is important to use the drug appropriately for patients who are in pain. Nausea, vomiting, respiratory depression, drowsiness, dizziness, constipation, difficulty in urination, biliary colic, and occasionally allergies such as itching, hives, and skin edema can occur. The symptoms of acute poisoning with this drug are coma, respiratory depression, appearance of extremely narrow pupils, symmetry on both sides, and pinpoint size, as well as decreased blood pressure and low urination. There can be a drop in body temperature, wet and cold skin, muscle weakness, and in severe cases, hypoxic shock, coma, circulatory failure, dilated pupils, and death. Morphine is mainly a strong analgesic for acute pain where other analgesics are ineffective, such as severe trauma, war injuries, burns, patients with advanced cancer, and when myocardial infarction with normal blood pressure can use this product for analgesia, which can reduce the burden on the heart. For cardiogenic asthma it can also provide temporary relief of pulmonary edema, and administered before anesthesia to enable the patient to enter a drowsy state. Morphine has an excitatory effect on smooth muscle, so it cannot be used alone for visceral colic, such as biliary colic, renal colic, etc. It should be used in combination with atropine, which has an antispasmodic effect.