Hyaluronic acid and Botox are among the products approved for use by the State Food Administration. Unless over-injected or frequently injected, there will be a stiff expression. Under the premise of regular hospitals, professional doctors and regular products, it is unlikely that there will be adverse reactions to years of Botox or hyaluronic acid injections. The difference between them, mainly in the following aspects: a. The mechanism of action is different Hyaluronic acid, or hyaluronic acid, is an essential substance for the human body, responsible for storing water, combined with water to increase the volume of the skin, so that the skin looks full, plump and elastic. Hyaluronic acid is commonly used in medical aesthetics for subcutaneous injections to fill wrinkles, depressions, and contouring. Botulinum toxin as a neurotoxin, when injected locally, binds to the sympathetic nerve terminal, blocks neuromuscular transmission and inhibits acetylcholine production, thus blocking nerve-to-muscle transmission. After injection, the overdeveloped muscles can be relaxed. Second, the injection level is different Third, the applicable symptoms are different Due to the different principles of action, the objects of treatment are also different. In terms of wrinkle removal, hyaluronic acid is only for static wrinkles, that is, wrinkles not related to expression, such as decreases in wrinkles. On the contrary, Botox is mainly for dynamic wrinkles, that is, wrinkles that appear only when you make expressions, such as crow’s feet, frown lines, head lines, etc. Fourth, the effect time is different After hyaluronic acid injection, you can generally see the effect of filling wrinkles immediately. After Botox injection, the effect can be seen in 10-15 days, and the best effect can be seen in about 2 months to 4 months. V. Adverse reactions are different (depending on individual conditions) 1. Hyaluronic acid: allergy, local redness, swelling, itching, pain, and tightness of the skin. 2.Botulinum toxin: muscle weakness, local redness, swelling, pain, stiffness of expression, difficulty in lifting eyes. Under normal circumstances, adverse reactions can be relieved in the short term.