Pancreatic cancer nerve metastasis is fast. The typical characteristic of pancreatic cancer is that the cancer cells metastasize and spread along the nerve sheath, and the speed of nerve metastasis is relatively fast, which will not only invade the nerves in the pancreas, but also spread outward along the nerves in the pancreas and invade the peripheral nerves of the pancreas, and the prognosis is relatively poor, and the surgery should also be followed by adjuvant chemotherapy and other treatments, so as to slow down the speed of recurrence and metastasis. In the process of surgical treatment, the main focus is on the pathway of nerve metastasis for nerve clearance. It should be noted that, since some organs in the retroperitoneum are adjacent to large blood vessels, the operation should be strictly standardized in the process of purging, so as to achieve the goal of radical block resection. It is recommended to actively cooperate with professional oncologists for examination and treatment in the early stage of pancreatic cancer, and formulate reasonable and effective therapeutic measures at an early stage, including surgical treatment, chemotherapy, etc., to control the nerve metastasis of tumor cells.