I have encountered a patient with hypothyroidism (severe liver insufficiency with edema) who had been hospitalized for half a month in a private hospital for autoimmune hepatitis before coming to our department. Under what circumstances should patients be considered to come to the endocrinology department to exclude endocrine diseases? 1, sudden unexplained weight loss with dry mouth and polyuria. 2. Recent weakness and blurred vision without any obvious cause. 3.Emotional, insomnia, palpitations, hand trembling, fear of heat, excessive sweating, hyperphagia, emaciation, increased frequency of stools, and weakness. 4.Sudden weakness of limbs (periodic paralysis) in men 5.Sudden scanty menstruation or amenorrhea in women. Short-term appearance of significant obesity with hirsutism, hypertension, etc. 6, persistent hypertension and or hypokalemia in young people 7, the appearance of protruding eyes, enlargement of the thyroid area in the neck or the appearance of a mass that can move up and down with swallowing. 8, fear of cold, swelling, generalized weakness, 9, patients with hyperlipidemia and hepatic insufficiency for which no other cause can be identified are recommended to check thyroid function. 10, Patients with tachycardia or frequent premature booms should also exclude thyroid disease. 11. Patients with generalized bone pain, severe osteoporosis, and repeated multiple fractures need to exclude hyperparathyroidism.