Patients with leukoaraiosis are mainly examined for the following: 1. The disease is also known as the triad of mouth, eyes and genitalia. Therefore, it is important to check for recurrent oral ulcers and genital ulcers, as well as uveitis and conjunctivitis of the eyes when leukoaraiosis is suspected.2. A variety of skin lesions can occur in leukoaraiosis: erythema nodosum, pseudofolliculitis are common.3. Needle prick reaction test: If pustules or small papules appear at the site of the needle prick after 1-2 days, the diagnosis is positive needle prick reaction, which is an important diagnostic indication of leukoaraiosis.4. 4, other tests: including blood tests for inflammatory indicators, autoantibodies and other laboratory tests, may appear leukocytosis, increased blood sedimentation, elevated C-reactive protein and other inflammatory indicators. Autoantibody tests include, for example, antinuclear antibody and antineutrophil antibody tests. Although these tests are not specific, they help to discharge other diseases.