Gastroscopy is not always necessary before taking quadruple drugs, and patients who are positive for H. pylori by carbon 13 or carbon 14 breath test should be treated with quadruple drugs. Quadruple therapy is currently used to eradicate H. pylori in clinical practice and consists of one proton pump inhibitor (omeprazole, lansoprazole, etc.), two antibiotics (amoxicillin, metronidazole, clarithromycin, norfloxacin, etc.), and one bismuth agent (bismuth potassium citrate, bismuth pectin, etc.). Quadruple therapy is mainly used for patients who are positive for Helicobacter pylori, including those who have a positive gastroscopy biopsy (taking gastric mucosal tissue for rapid urease test), carbon 13 breath test and carbon 14 breath test. Therefore, gastroscopy is not always necessary before taking tetracycline. Since H. pylori infection is closely related to the development of chronic gastritis, peptic ulcer, gastric cancer and other diseases, once the examination finds that H. pylori is positive need to consult a doctor in time for eradication treatment. The medication should be taken in strict accordance with the doctor’s prescription, and should not be used on its own, so as not to delay or even aggravate the condition.