Coughing while sleeping may be related to cough variant asthma, gastroesophageal reflux disease, cardiovascular system diseases, etc. The cause should be identified and medication should be administered according to the etiology. 1. Cough variant asthma: it is a special type of asthma that often attacks in the early hours of the morning or early in the morning, with paroxysmal dry cough as the only symptom. Commonly used inhaled glucocorticoid treatment, such as budesonide powder inhaler. 2. Gastroesophageal reflux disease (GERD): when lying down, it can lead to reflux of gastric contents into the throat and airway, resulting in coughing, heartburn, chest tightness and other symptoms during sleep. Commonly used proton pump inhibitors such as omeprazole, gastric power drugs such as mosapride and other medications. 3. Cardiovascular system diseases: especially left heart failure, due to the redistribution of blood during sleep lying down so that the increase in pulmonary blood volume, while at the same time the night vagal tone increases, small bronchial constriction, resulting in patients with cough, nocturnal paroxysmal dyspnea and other symptoms. Cardiotonic and diuretic drugs such as digoxin, cediran, furosemide and hydrochlorothiazide are given to address the cause. There are many diseases that cause coughing during sleep, such as postnasal drip syndrome and infectious diseases of the respiratory tract. If the symptoms continue to be unrelieved or aggravated, it is recommended to consult a doctor in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.