Osteoarthritis is a common disease in the elderly, and its risk factors include the following: 1, age: age is the biggest risk factor, with age, it has been observed that with age can occur three main changes: the incidence gradually increased; chondrocyte division and proliferation function gradually weakened; chondrocyte synthesis of cartilage proteoglycan quality and quantity decline 2, sex hormones: before the age of 50 years old, men and women suffer from osteoarthritis 3, obesity: obesity increases the load on the weight-bearing joints, weight gain and the incidence of osteoarthritis of the knee is proportional 4, excessive wear and tear of the joints: excessive load (obesity) or uneven load on the joints (uncoordinated movement), any cause of abnormalities in the shape of the joints can be localized to the cartilage surface of the joints 5, injury and infection: any lesion that can damage cartilage, such as infection, toxins, injury, etc., can be secondary to the disease 6, insufficient muscle support: such as too little exercise, can cause muscle strength is reduced, the support of the joint and coordination ability is reduced, is the 7, abnormal bone density: when the subchondral bone trabeculae become thin and hard, osteoporosis, its ability to withstand the pressure is reduced 8, genetic predisposition: osteoarthritis patients tend to have a family tendency to gather. Hip and carpometacarpal joint osteoarthritis is more common in Caucasians. Genetic analysis of biploidy in osteoarthritis found that mutations in the 23-35 region on the short arm of chromosome 2 were associated with osteoarthritis. Osteoarthritis may also be associated with the type II procollagen gene responsible for encoding type II collagen in cartilage. In particular, offspring of patients with distal interphalangeal nodes of the hand are prone to osteoarthritis.