Spots on the face may be chloasma, freckles, etc. Different diseases are treated with different medications, and there is no such thing as what is good to be used, which should be treated with topical or oral medications according to the condition as prescribed by the doctor, and physical therapy is carried out when necessary. 1. Chloasma: mostly related to genetic susceptibility, ultraviolet radiation and other factors, mostly seen in the prominent part of cheekbones, upper lip and nose, with lesions of light yellowish brown or dark coffee-colored spots, and deepening of pigmentation after sun exposure. They should do a good job of sun protection and follow the doctor’s instruction to use hydroquinone, azelaic acid, vitamin A acid, etc. They can also take vitamin C, glutathione, etc. by mouth. 2. Freckles: It is an autosomal dominant disease, mostly distributed in the exposed areas, such as bilateral cheeks, nose, etc. The lesions are yellowish, yellowish brown round or irregular spots. Hydroquinone, retinoic acid, vitamin E cream, etc. can be used as prescribed by the doctor to improve the symptoms, and physical therapy such as intense pulsed light, Q laser, etc. can be carried out if necessary. In addition, there are many other reasons that can cause spots on the face, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease, and then receive treatment as soon as possible.