Uremia may lead to elevated parathyroid hormone. Patients with uremia may develop secondary hyperparathyroidism, in which the production of parathyroid hormone (PTH) is increased, leading to an accumulation of PTH in the body. The mechanism of occurrence is associated with disturbances in PTH regulation such as metabolic disorders of low calcium and high phosphorus, down-regulation of calcium-sensitive receptors and decreased levels of active vitamin D, which ultimately lead to elevated PTH levels. The weakened ability of renal tubular secretion of H+ and reabsorption of HCO3- in patients with uremia may lead to the development of metabolic acidosis in patients, and when the body develops metabolic acidosis, its ability to synthesize active vitamin D is weakened, stimulating the secretion of PTH by parathyroid cells, which may exacerbate the secondary hyperparathyroidism in patients. When uremic patients with elevated parathyroid hormone, it is recommended to go to the regular hospital in time, under the guidance of the doctor standardized treatment.