The Rome Index, also known as the Ovarian Malignancy Risk Algorithm, is calculated according to a specific formula to assess the risk of developing ovarian cancer and is important for early diagnosis of ovarian cancer. The Roma Index assesses the risk of ovarian cancer in women with preoperative pelvic masses by combining the values of two tumor markers, HE4 and CA125, as well as the patient’s menstrual status. The Rome Index is applicable to female patients with pelvic masses detected by pelvic examination, ultrasonography or CT. The formula is as follows. Pre-menopausal predictive index: (PI)=-12.0+2.38×LN(HE4)+0.0626×LN(CA125). Postmenopausal predictive index: (PI)=-8.09+1.04×LN(HE4)+0.732×LN(CA125). (LN denotes natural logarithm) Roman index value = exp(PI)/[1+exp(PI)] × 100 The standardized Roman Index values are as follows. 1. Premenopausal: ROMA value <11.4% a low risk of ovarian cancer; ROMA value ≥11.4% a high risk of ovarian cancer. 2. Postmenopausal: ROMA value <29.9% a low risk of ovarian cancer; ROMA value ≥29.9% a high risk of ovarian cancer. ROMA is one of the important indicators for evaluating the risk of ovarian cancer, and the accuracy of the test value is relatively high. Clinicians can judge the risk of ovarian cancer early and intervene in the treatment and prognosis of patients according to the results of the ROMA test and the specific conditions of the patients, which is of great significance for clinical application.