Omeprazole and pantoprazole both work by suppressing stomach acid and treating stomach problems with similar side effects, mainly in fractures, vitamin absorption disorders, and digestive symptoms. 1. Fractures: increased tendency to fracture in the wrist and spine. Most often occurs in the hips, wrists and spine. Long-term application of the drug, patients with spine wrist joint pain and other symptoms should seek medical attention. Daily sun exposure or through calcium supplements to prevent side effects. 2. Vitamin absorption disorders: it reduces the absorption of vitamin B12, thus leading to B12 deficiency and unevenness, which in turn leads to the occurrence of anemia. 3. Digestive symptoms: both drugs are highly effective in suppressing stomach acid, but if a person with insufficient stomach acid is already suffering from indigestion, suppressing stomach acid will aggravate the condition, and there are also people with constipation who take omeprazole, which will be even more pronounced. These two drugs still have other side effects such as headache, memory loss, etc., the use of drugs need to be under the guidance of a physician, clearly meet the indications for the application.