Nucleoside analogs are commonly used in the treatment of hepatitis B virus, the advantages are strong, fast-acting, and more accurate efficacy, and the disadvantage is that some nucleoside analogs have certain side effects. The main function of nucleotide drugs is to inhibit the replication of hepatitis B virus to treat hepatitis B. The advantages are strong effect, fast onset of action and better efficacy. However, the use of nucleotide drugs for the treatment of hepatitis B will have certain side effects, the side effects are mainly based on the type of drug has a lot to do with, for example, the current commonly used entecavir, a small number of patients may appear after the use of fatigue, fatigue, and may have gastrointestinal symptoms. Some patients are likely to cause fluctuation or even elevation of aminotransferases at an early stage as well as possible lactic acidosis. There is also the commonly used antiviral drug tenofovir, which may cause adverse reactions such as osteoporosis and renal impairment in some patients. In the process of using nucleotide drugs, attention should be paid to timely review, to assess the effectiveness of treatment, and at the same time to be alert to the possibility of drug side effects, but also need to be alert to the emergence of the possibility of drug resistance. The use of medication should be carried out under the guidance of a doctor.