Total bilirubin 28.3 μmol/L direct bilirubin, 7.2 μmol/L, indirect bilirubin 21.1 μmol/L, may be due to drug liver injury, viral hepatitis, fatty liver, etc., and can be treated with hepatoprotective, antiviral drugs as well as improvement of lifestyle. 1. Pharmacological liver injury: patients taking anti-tumor chemotherapeutic drugs, anti-tuberculosis drugs, antipyretic and analgesic drugs, immunosuppressant drugs, hypoglycemic and lipid-lowering drugs, and antiviral drugs, etc., will lead to pharmacological liver injury, resulting in increased bilirubin, which will be relieved after stopping the drugs, and can take hepatoprotective drugs, such as compound glycyrrhizin tablets and other treatments. 2. Viral hepatitis: viral hepatitis is caused by hepatitis virus infection, which will cause bilirubin uptake and excretion disorders at the same time, manifested as direct bilirubin and indirect bilirubin elevation at the same time, you can take antiviral drugs for treatment, such as entecavir. 3. Fatty liver: a disease caused by abnormal fat deposition in the liver due to various reasons, which leads to the metabolism of the liver itself being affected, and then bilirubin will be elevated, and the patient can be treated by improving the lifestyle, such as appropriate exercise, regular diet, and so on. Bilirubin elevation may be caused by other reasons, if the patient has elevated bilirubin, should promptly go to the hospital for standardized treatment to prevent the development of the condition of the above drugs need to be used under the guidance of a doctor, do not self-medication.