The main clinical manifestations of IgA nephropathy are painless hematuria and proteinuria, and the grading of IgA nephropathy mainly depends on the pathological condition of renal puncture biopsy, which is Lee’s grading, and it is divided into I to V. The specific manifestations of each grade are different, and cannot be generalized. The specific manifestations of each grade are different and cannot be generalized. 1. Grade I: The glomerular mesangial area has only mild mesangial hyperplasia. 2. Grade II: Moderate proliferation of the membranes, no crescent formation, and no involvement of tubular function. 3. Grade III: Extensive diffuse thylakoid hyperplasia, usually not severe, with crescent formation, but rare. There is usually no tubular atrophy. 4. Grade IV: Most of the glomeruli will have thylakoid proliferation, and may be accompanied by glomerulosclerosis, crescent formation, tubular atrophy, interstitial fibrosis and so on. 5. Grade V: Its performance becomes more serious on the basis of grade IV. More than half of the glomerulosclerosis and more serious tubular damage. If IgA Nephropathy is diagnosed, it is recommended to go to the hospital for examination in time to clarify the grade and follow the doctor’s instruction for active treatment.