Whether or not high bilirubin will cause generalized itching cannot be generalized due to different causes. If it is due to physiologic jaundice, it usually does not cause generalized itching. However, if it is caused by hepatitis, bile duct stones, etc., it will usually cause itching all over the body. 1. Physiologic jaundice: Physiologic jaundice occurs when bilirubin production is greater than excretion during the first 2 days of a newborn’s life. In such cases, the newborn is in good spirits and does not have itchy skin. 2. Hepatitis: High bilirubin can also be caused by hepatitis, which often presents with a hepatic face, itchy skin, dullness and lack of luster. Patients may also have different degrees of nausea, loss of appetite, abdominal distension, diarrhea and other symptoms. 3. Bile duct stones: High bilirubin is also considered to be caused by bile duct stones. Patients with bile duct stones may experience itching of the skin, accompanied by yellowing of the sclera and mucous membranes of the skin. Patients may also present with abdominal pain, high fever, and jaundice. Symptoms such as epigastric discomfort. There are many causes of high bilirubin, and patients are advised to go to regular hospitals in time to find out the cause of the disease.