Early stage liver cancer usually has no obvious symptoms, and if it is located under the hepatic pericardium, pain will appear only when there is pulling of the pericardium, and right shoulder pain will seldom appear. Early stage liver cancer usually has no obvious symptoms and seldom presents right shoulder pain. As liver belongs to intraperitoneal organs, liver cancer in advanced stage will only appear enlargement and swelling of liver tissue, and the liver peritoneum will be stretched, and the patient will have pain in the right upper abdomen, and there may be pain radiating to the back of the right shoulder, and the back of the shoulder may also have the pain symptom of aching, which is accompanied with nausea, vomiting, fatigue, loss of appetite, and anorexia of greasy and fat. Liver cancer patients should actively choose surgical treatment in early stage, and for patients with advanced liver cancer, if persistent pain occurs, it cannot be ruled out that it is combined with bone metastasis. In addition, shoulder pain can not be excluded to be caused by localized frozen shoulder and other diseases, so patients should actively consult the doctor, improve relevant examination and make clear diagnosis.