The treatment of prostate cancer bone metastasis pain is based on comprehensive treatment, mainly anti-tumor therapy, symptomatic treatment. Prostate cancer is one of the most common malignant tumors in male reproductive system, and more than 90% of patients will have bone metastasis. The pain brought by bone metastasis seriously affects the quality of life of patients, and has a wide range of effects on the physical and psychological aspects of patients. Prostate cancer bone metastasis pain treatment is comprehensive treatment, which is mainly divided into two parts: 1. Anti-tumor therapy: anti-tumor therapy for prostate cancer itself is the basis of all treatments, effective anti-tumor therapy can both relieve pain and control tumor progression. Commonly used methods include surgery, radiotherapy, chemotherapy, endocrine therapy, targeted therapy and bisphosphonate drugs. 2. Symptomatic treatment: pain relief treatment, including drug pain relief and local radiotherapy pain relief. For mild pain, non-steroidal drugs such as ibuprofen can be used; for moderate or severe pain, opioids such as morphine can be used. For localized pain is obvious, the effect of drug treatment is not good patients can choose local radiotherapy for pain relief. If there is any discomfort, the treatment should be standardized under the guidance of a specialist, and should not be taken blindly on its own, so as not to cause adverse effects on the body.