For patients with dry mouth and eyes symptoms, especially women, relevant immune indexes should be checked to exclude dry syndrome. ana, anti-SSA antibody, anti-SSB antibody, anti-dsDNA antibody, etc. can be positive in dry syndrome. Especially, anti-SSA antibody and anti-SSB antibody have greater significance for the diagnosis of dry syndrome. Among them, the positive rate of anti-SSB antibody in this disease is lower than that of anti-SSA antibody, but the positive rate of anti-SSB antibody in other rheumatic immune diseases is very low, so it is specific for the diagnosis of desiccation syndrome. In addition, RF is also positive in dry syndrome, and it is mostly high potency positive. Therefore, patients with dry mouth and eyes, joint swelling and pain, and heavy RF titers especially need to check autoantibodies to exclude dry syndrome.